GMAP: a genomic mapping and alignment program for mRNA and EST sequences
نویسندگان
چکیده
منابع مشابه
GMAP: a genomic mapping and alignment program for mRNA and EST sequences
Motivation: We introduce gmap, a standalone program for mapping and aligning cDNA sequences to a genome. The program maps and aligns a single sequence with minimal startup time and memory requirements, and provides fast batch processing of large sequence sets. The program generates accurate gene structures, even in the presence of substantial polymorphisms and sequence errors, without using pro...
متن کاملGMAP: a genomic mapping and alignment program for mRNA and EST sequence
MOTIVATION We introduce GMAP, a standalone program for mapping and aligning cDNA sequences to a genome. The program maps and aligns a single sequence with minimal startup time and memory requirements, and provides fast batch processing of large sequence sets. The program generates accurate gene structures, even in the presence of substantial polymorphisms and sequence errors, without using prob...
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Splicing is a biological phenomenon that removes the non-coding sequence from the transcripts to produce a mature transcript suitable for translation. To study this phenomenon, information on the intron-exon arrangement of a gene is essential, usually obtained by aligning mRNA/EST sequences to their cognate genomic sequences. MGAlign is a novel, rapid, memory efficient and practical method for ...
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MGAlign, a Reduced Search Space Approach to the Alignment of mRNA Sequences to Genomic Sequences
Alternative splicing is a cellular process that accounts for protein diversity in higher eukaryotes. As much as 60% of the human genome (Kan et al., 2001) and 41% of the mouse genome (FANTOM Consortium, 2002) are alternatively spliced. Methods currently available specifically for aligning mRNA sequences to their cognate genomic sequence has include sim4 (Florea et al., 1998) and Spidey (Wheelan...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2005
ISSN: 1367-4803,1460-2059
DOI: 10.1093/bioinformatics/bti310